About the Company
InSight Surgical Technologies, Inc. (IST) is a clinical phase, medical technology company developing autonomous updated surgical navigation systems for digital surgery that augment the surgeon’s view of the evolving operative field to enhance surgical treatment. The company will commercialize products that provide real-time, ML/AI-enhanced, intraoperative guidance via image updating and quantitative fluorescence imaging to enable faster, less invasive, more accurate, personalized treatment of tumors and to improve the clinical outcomes of standard and robotic surgical resections.
The company was founded in October 2017 by senior members of a long-standing NIH-funded research collaboration involving faculty at Dartmouth College (including the Thayer School of Engineering, the Geisel School of Medicine and the Tuck School of Business) and University Health Network (UHN), Toronto. The company is based near Dartmouth College in Lebanon, NH, in close proximity to the nationally-recognized, tertiary-care Dartmouth Hitchcock Medical Center.
IST has a strong intellectual property portfolio and deep domain experience in both surgical navigation and quantitative fluorescence imaging technologies. The company has been awarded five separate SBIR grants (>$6.5M) to develop proprietary prototypes for these technologies. The deployment of these technologies for both low- and high-grade glioma as well as benign and metastatic tumor will significantly improve treatment outcomes relative to today’s standard-of-care surgery. IST has an exclusive license to 21 granted patents and multiple pending applications.
The Management Team
& Board Director
Careers
If you are interested in what we do and believe you have the passion, experience and expertise to join the Insight Surgical Technologies team, please send your CV or resume along with a covering letter to info [at] insightsurgicaltechnologies [dot] com.
Selected Publications
Navigation
- Roberts DW, Hartov A, Kennedy FE, Miga MI, Paulsen KD: Intraoperative brain shift and deformation: a quantitative analysis of cortical displacement in 28 cases. Neurosurgery 43:749-760, 1998.
- Paulsen KD, Miga MI, Kennedy FE, Hoopes PJ, Hartov A, Roberts DW: A computational model for tracking subsurface tissue deformation during stereotactic neurosurgery. IEEE Transactions on Biomedical Engineering, 46:213-225, 1999.
- Roberts DW, Miga MI, Hartov A, Eisner S, Lemery JM, Kennedy FE, Paulsen KD: Intraoperatively updated neuroimaging using brain modeling and sparse data. Neurosurgery 45:1199-1207, 1999.
- Ji S, Roberts DW, Hartov A, Paulsen KD: Intraoperative patient registration using volumetric true 3D ultrasound without fiducials. Med Phys 39(12):7540-7552, 2012. PMID:23231302
- Fan X, Roberts DW, Ji S, Hartov A, Paulsen KD: Intraoperative fiducial-less patient registration using volumetric 3D ultrasound: a prospective series of 32 neurosurgical cases. J Neurosurg Sep;123(3):721-31, 2015. [Epub 2015 Jul 3] PMID: 26140481
- Fan X, Roberts DW, Schaewe TJ, Ji S, Holton LH, Simon DA, Paulsen KD. Intraoperative image updating for brain shift following dural opening. J Neurosurg 126:1924-1933, 2017. PubMed PMID: 27611206. PMCID: PMC5549265.
- Fan X, Roberts DW, Olson JD, Ji S, Paulsen KD: Automatic intraoperative fiducial-less patient registration using cortical surface. Proc. SPIE 10135, Medical Imaging 2017: Image-Guided Procedures, Robotic Interventions, and Modeling, 101352I (3 March 2017); doi: 10.1117/12.2254471
- Fan X, Roberts DW, Olson JD, Ji S, Schwaewe, Simon DA, Paulsen KD. Image updating for brain shift compensation during resection. Operative Neurosurgery 14:402-411, 2018. DOI: 10.1093/ons/opx123.
- Fan X, Roberts DW, Olson JD, Li C, Paulsen KD: Image updating for brain deformation compensation: cross-validation with intraoperative ultrasound. Proc. SPIE 10576, Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling, 105760S (13 March 2018); doi: 10.1117/12.2293724
- Lollis SS, Fan X, Evans L, Olson JD, Paulsen KD, Roberts DW, Mirza SK, Ji S. Use of Stereovision for Intra-operative Co-registration of a Spinal Surgical Field: A Human Feasibility Study. Operative Neurosurgery 14: 29-35, 2018. DOI: 10.1093/ons/opx132.
Fluorescence
- Kim A, Khurana M, Moriyama Y, Wilson BC: Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements. J Biomed Opt 15:067006, 2010
- Kim A, Dadani F, Wilson BC: A fiberoptic reflectance probe with multiple source-collector separations to increase the dynamic range of derived tissue optical absorption and scattering coefficients. Optics Express 18:5580-5594, 2010.
- Valdes PA, Leblond F, Kim A, Harris BT, Wilson BC, Fan X, Tosteson TD, Hartov A, Ji S, Erkmen K, Simmons NE, Paulsen KD, Roberts DW: Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker. J Neurosurg 115(1):11-17, Jul 2011 [epub 2011 Mar 25]. PMID: 21529179
- Valdes PA, Kim A, Leblond F, Conde O, Harris BT, Paulsen KD, Wilson B, Roberts DW: Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high- grade glioma surgery. J Biomedical Optics 16(11):11607-1-14, 2011.
- Valdes PA, Kim A, Brantsch M, Niu C, Moses ZB, Tosteson TD, Wilson BC, Paulsen KD, Roberts DW, Harris BT: 5-Aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathological markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy. Neuro-Oncology 13(8):846-856, Aug, 2011. PMID: 21798847
- Valdes PA, Leblond F, Jacobs VL, Wilson BC, Paulsen KD, Roberts DW: Quantitative, spectrally-resolved intraoperative fluorescence imaging. Sci Rep 2:798, 2012. [Epub 2012 Nov 1]. PMID:23152935
- Valdes PA, Bekelis K, Harris BT, Wilson BC, Leblond F, Kim A, Simmons NE, Erkmen K, Paulsen KD, Roberts DW: 5-Aminolevulinic-acid-induced protoporphyrin IX fluorescence in meningioma: Qualitative and quantitative measurements in vivo. Neurosurg March 10 Suppl 1:74-82, 2014. [Epub 2013 July 24]. PMID: 23887194
- Valdes PA, Jacobs V, Harris BT, Wilson BC, Leblond F, Paulsen KD, Roberts DW: Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery. J Neurosurg. Sep;123(3):771-80, 2015. [Epub 2015 Jul 3] PMID 26140489
- Bravo JJ, Olson JD, Davis SC, Roberts DW, Paulsen KD, Kanick SC. Hyperspectral data processing improves PpIX contrast during fluorescence guided surgery of human brain tumors. Sci Rep 7:9455, 2017. DOI: 10.1038/s41598-017-09727-8. PMCID: PMC5572708.
- Widhalm G, Olson J, Weller J, Bravo J, Han SJ, Phillips J, Hervey-Jumper S, Chang S, Roberts DW, Berger MS. The value of visible 5-ALA fluorescence and quantitative protoporphyrin IX analysis for improved surgery of suspected low-grade gliomas. J Neurosurg (Published online 2019) DOI:https://doi.org/10.3171/2019.1.JNS182614)
